LY 303511 hydrochloride
Code | Size | Price |
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TAR-T4423-1mg | 1mg | £97.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4423-5mg | 5mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4423-1mL | 1 mL * 10 mM (in DMSO) | £138.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4423-10mg | 10mg | £173.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4423-25mg | 25mg | £282.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4423-50mg | 50mg | £466.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4423-100mg | 100mg | £647.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
LY303511 (NV-128)is a potent mTOR inhibitor
CAS:
2070014-90-1
Formula:
C19H19ClN2O2
Molecular Weight:
342.82
Pathway:
Membrane transporter/Ion channel; Apoptosis; PI3K/Akt/mTOR signaling
Purity:
0.9671
SMILES:
Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
Target:
Potassium Channel; TNF; mTOR
References
Tucker-Kellogg L,etal.Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511.Biochem Pharmacol. 2012 Nov 15;84(10):1307-17.
Shenoy K,etal.LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors.Cancer Res. 2009 Mar 1;69(5):1941-50.
Shi Y,etal.Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP.Bioinformatics. 2013 Feb 1;29(3):347-54.