(-)-Alkannin
| Code | Size | Price |
|---|
| TAR-T4958-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4958-20mg | 20mg | £119.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
CAS:
517-88-4
Formula:
C16H16O5
Molecular Weight:
288.299
Pathway:
PI3K/Akt/mTOR signaling; Apoptosis
Purity:
0.9981
SMILES:
CC(C)=CC[C@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
Target:
Apoptosis; PI3K
References
Qu D , Xu X , Zhang M , et al. Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling. Molecular Medicine Reports, 2015.
Gara R K , Srivastava V K , Duggal S , et al. Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway[J]. Journal of Biomedical Science, 2015, 22(1):26.
Takano-Ohmuro H , Yoshida L S , Yuda Y , et al. Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity[J]. Inflammation Research, 2008, 57(10):484-488.
Xu J, Wang Q, Leung E L H, et al. Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell lung cancer[J]. Frontiers of Medicine. 2020, 14(1): 60-67.
Zhang Z Z, Wen C H, Jia M, et al. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor?associated macrophages by upregulating PTEN. The Kaohsiung Journal of Medical Sciences. 2022
Liu J P , Liu D , Gu J F , et al. Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC?803 via the Toll?like receptor 2/nuclear factor?kappa B pathway[J]. Journal of Pharmacy & Pharmacology, 2015, 67(8):1143-1155.
Xu J, Wang Q, Leung E L H, et al. Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell lung cancer. Frontiers of Medicine. 2020, 14(1): 60-67.
Xue W, et al. Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice. Cell Physiol Biochem. 2018;45(6):2461-2470.