ISOGINKGETIN
| Code | Size | Price |
|---|
| TAR-T4S21320-5mg | 5mg | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
1. Isoginkgetin, a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. 2. Isoginkgetin has anti-tumor activity, the mechanistic basis is splicing inhibition , thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.3. Isoginkgetin can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. 4. Isoginkgetin (0.3mg/kg ip for 3d) can reduce the level of O2?- in plasma and erythroeyte and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.
CAS:
548-19-6
Formula:
C32H22O10
Molecular Weight:
566.518
Pathway:
Proteases/Proteasome;
Purity:
0.9972
SMILES:
COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3OC)-c3cc(=O)c4c(O)cc(O)cc4o3)c2o1
Target:
MMP;
References
Theerawatanasirikul S, Thangthamniyom N, Kuo C J, et al. Natural Phytochemicals, Luteolin and Isoginkgetin, Inhibit 3C Protease and Infection of FMDV, In Silico and In Vitro. Viruses. 2021, 13(11): 2118.
Suhua P . Effect of Isoginkgetin on Scavenge of Oxygen Free Radical in Anoxic Rats[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 1993.
Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762.