GSK4112
Code | Size | Price |
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TAR-T5045-5mg | 5mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T5045-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T5045-10mg | 10mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T5045-25mg | 25mg | £201.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T5045-50mg | 50mg | £308.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T5045-100mg | 100mg | £497.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
CAS:
1216744-19-2
Formula:
C18H21ClN2O4S
Molecular Weight:
396.89
Pathway:
Autophagy
Purity:
0.9969
SMILES:
CC(C)(C)OC(=O)CN(Cc1ccc(s1)[N+]([O-])=O)Cc1ccc(Cl)cc1
Target:
Autophagy
References
Liu Q, Xu L, Wu M, et al. Rev-erb? exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy. Cell & Bioscience. 2021, 11(1): 1-15.
Xu L, yi Zhou W, Xu T, et al. Rev-erb? Mediates Steatosis in Alcoholic Fatty Liver Through Regulating Autophagy. Cell & Bioscience. 2021 Jul 10;11(1):129. doi: 10.1186/s13578-021-00622-4.
Grant D, et al. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erb?. ACS Chem Biol. 2010 Oct 15;5(10):925-932.
Xu L, yi Zhou W, Xu T, et al. Rev-erb? Mediates Steatosis in Alcoholic Fatty Liver Through Regulating Autophagy[J]. bioRxiv. 2021