AMAROGENTIN
| Code | Size | Price |
|---|
| TAR-T5497-10mg | 10mg | £151.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis
CAS:
21018-84-8
Formula:
C29H30O13
Molecular Weight:
586.546
Pathway:
PI3K/Akt/mTOR signaling; Chromatin/Epigenetic; Apoptosis
Purity:
0.98
SMILES:
[H][C@@]12CCOC(=O)C1=CO[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1OC(=O)c1c(O)cc(O)cc1-c1cccc(O)c1)[C@@H]2C=C
Target:
Apoptosis; AMPK
References
Zhao, J.G., Zhang, L., Xiang, X.-j.,?et al.?Amarogentin secoiridoid inhibits?in vivo?cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway.?J. BUON.?21(3),?609-617?(2016).
Shantanu S , Khushboo B , Durai S , et al. The Bitter Barricading of Prostaglandin Biosynthesis Pathway: Understanding the Molecular Mechanism of Selective Cyclooxygenase-2 Inhibition by Amarogentin, a Secoiridoid Glycoside from Swertia chirayita[J]. PLoS ONE, 2014, 9(3):e90637-.
Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891.