Degrasyn
Code | Size | Price |
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TAR-T6300-5mg | 5mg | £117.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6300-1mL | 1 mL * 10 mM (in DMSO) | £121.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6300-10mg | 10mg | £153.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6300-25mg | 25mg | £238.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6300-50mg | 50mg | £373.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6300-100mg | 100mg | £519.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Degrasyn (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT).
CAS:
856243-80-6
Formula:
C19H18BrN3O
Molecular Weight:
384.277
Pathway:
Autophagy; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; Ubiquitination; Angiogenesis; Apoptosis; DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9998
SMILES:
CCC[C@H](NC(=O)C(=Cc1cccc(Br)n1)C#N)c1ccccc1
Target:
Apoptosis; Bcr-Abl; DUB; Autophagy
References
Yan B, Guo J, Wang Z, et al.The ubiquitin?specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression.MedComm.2023, 4(4): e337.
Bartholomeusz GA, et al. Blood, 2007, 109(8), 3470-3478.
Kapuria V, et al. Cancer Res, 2010, 70(22), 9265-9276.
Luo H, Jing B, Xia Y, et al. WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia[J]. Cancer Cell International. 2019 Mar 13;19:56.
Luo H, Jing B, Xia Y, et al. WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia. Cancer Cell International. 2019 Mar 13;19:56
Bartholomeusz G, et al. Cancer Res, 2007, 67(8), 3912-3918.