4μ8C
Code | Size | Price |
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TAR-T6363-5mg | 5mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6363-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6363-10mg | 10mg | £117.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6363-25mg | 25mg | £149.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6363-50mg | 50mg | £193.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6363-100mg | 100mg | £258.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6363-500mg | 500mg | £539.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
4μ8C(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.
CAS:
14003-96-4
Formula:
C11H8O4
Molecular Weight:
204.181
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9861
SMILES:
Cc1cc(=O)oc2c(C=O)c(O)ccc12
Target:
IRE1
References
Cai J, Zhang X, Chen P, et al. The ER stress sensor inositol-requiring enzyme 1? in Kupffer cells promotes hepatic ischemia-reperfusion injury. Journal of Biological Chemistry. 2021: 101532.
Cross BC, et al. Proc Natl Acad Sci U S A. 2012, 109(15), E869-878.
Chen Y, Wu Z, Huang S, et al. Adipocyte IRE1? promotes PGC1? mRNA decay and restrains adaptive thermogenesis. Nature Metabolism. 2022: 1-19.
Kemp KL, et al. J Biol Chem. 2013, 288(46), 33272-33282.
Luo R, Wei Y, Chen P, et al.Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1? Branch of the Endoplasmic Reticulum Stress Response.Stem Cells International.2023, 2023.
Gao K, Yi Y, Xue Z, et al.Downregulation of XBP1s aggravates lipopolysaccharide-induced inflammation by promoting NF-?B and NLRP3 pathways? activation in goat endometrial epithelial cells.Theriogenology.2023