Gigantol
Code | Size | Price |
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TAR-TL0008-1mg | 1mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TL0008-1mL | 1 mL * 10 mM (in DMSO) | £205.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TL0008-5mg | 5mg | £216.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TL0008-10mg | 10mg | £289.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TL0008-25mg | 25mg | £422.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TL0008-50mg | 50mg | £551.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-TL0008-100mg | 100mg | £756.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity.
CAS:
67884-30-4
Formula:
C16H18O4
Molecular Weight:
274.316
Pathway:
Cytoskeletal Signaling; Metabolism; Stem Cells
Purity:
0.9873
SMILES:
COc1cc(O)cc(CCc2ccc(OC)c(O)c2)c1
Target:
Wnt/beta-catenin; Glucosidase
References
Yu S, et al. Gigantol inhibits Wnt/?-catenin signaling and exhibits anticancer activity in breast cancer cells:[J]. Bmc Complementary & Alternative Medicine, 2018, 18(1):59.
Chen H, et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-?B signaling pathway[J]. Oncology Reports, 2017, 37(2):865.
Wu J, et al. Gigantol from Dendrobium chrysotoxum, Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro, mechanistic study[J]. Journal of Ethnopharmacology, 2017, 198:255-261.
Chen H, et al. Protective effect of gigantol against hydrogen peroxide?induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.[J]. Molecular Medicine Reports, 2018, 17(2):3267-3273.