Ecdysone
| Code | Size | Price |
|---|
| TAR-TN3910-5mg | 5mg | £371.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN3910-1mL | 1 mL * 10 mM (in DMSO) | £414.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
CAS:
3604-87-3
Formula:
C27H44O6
Molecular Weight:
464.63
Pathway:
Metabolism; Autophagy; Apoptosis; Endocrinology/Hormones; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
C[C@H]([C@H](O)CCC(C)(C)O)C1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)C3CC[C@]12C
Target:
Apoptosis; ATPase; Glucocorticoid Receptor; Potassium Channel; Sodium Channel; Endogenous Metabolite; Autophagy
References
Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3? Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225.
Gautam NK, Verma P, Tapadia MG. Ecdysone regulates morphogenesis and function of Malpighian tubules in Drosophila melanogaster through EcR-B2 isoform. Dev Biol. 2015 Feb 15;398(2):163-76.
Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645.
Nishita Y. Ecdysone response elements in the distal promoter of the Bombyx Broad-Complex gene, BmBR-C. Insect Mol Biol. 2014 Jun;23(3):341-56.