Remogliflozin
| Code | Size | Price |
|---|
| TAR-T24708-50mg | 50mg | £695.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24708-100mg | 100mg | £1,066.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively).
CAS:
329045-45-6
Formula:
C23H34N2O7
Molecular Weight:
450.532
Purity:
0.98
SMILES:
CC(C)Oc1ccc(Cc2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)nn(C(C)C)c2C)cc1
References
1. Sadurn? A, Kehr G, Ahlqvist M, Wernevik J, Sj?gren HP, Kankkonen C, Knerr L, Gilmour R. Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes. Chemistry. 2018 Feb 26;24(12):2832-2836. doi: 10.1002/chem.201705373. Epub 2017 Dec 20. PubMed PMID: 29211300.
2. Dash RP, Babu RJ, Srinivas NR. Comparative pharmacokinetics of three SGLT-2 inhibitors sergliflozin, remogliflozin and ertugliflozin: an overview. Xenobiotica. 2017 Nov;47(11):1015-1026. doi: 10.1080/00498254.2016.1247219. Epub 2016 Oct 28. Review. PubMed PMID: 27718782.
3. Madaan T, Akhtar M, Najmi AK. Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. Eur J Pharm Sci. 2016 Oct 10;93:244-52. doi: 10.1016/j.ejps.2016.08.025. Epub 2016 Aug 12. Review. PubMed PMID: 27531551.
4. Kobayashi M, Isawa H, Sonehara J, Kubota M, Ozawa T. O-Glycosylation of 4-(Substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one Derivatives with 2,3,4,6-Tetra-O-acyl-?-D-glucopyranosyl Bromide via N1-Acetylation of the Pyrazole Ring. Chem Pharm Bull (Tokyo). 2016;64(7):1009-18. doi: 10.1248/cpb.c15-00982. PubMed PMID: 27373664.