Methotrexate 1-methyl ester
| Code | Size | Price |
|---|
| TAR-T25796-10mg | 10mg | £342.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25796-100mg | 100mg | £1,306.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Methotrexate 1-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic.
CAS:
66147-29-3
Formula:
C21H24N8O5
Molecular Weight:
468.474
Purity:
0.98
SMILES:
COC(=O)[C@H](CCC(O)=O)NC(=O)c1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1
References
1. Henderson GB, Tsuji JM. Methotrexate efflux in L1210 cells. Kinetic and specificity properties of the efflux system sensitive to bromosulfophthalein and its possible identity with a system which mediates the efflux of 3',5'-cyclic AMP. J Biol Chem. 1987 Oct 5;262(28):13571-8. PubMed PMID: 2820975.
2. Gewirtz DA, Randolph JK, Jaramillo M. Induction of methotrexate release from rat hepatocytes in suspension by alpha-adrenergic agents: involvement of calcium and metabolic energy. Arch Biochem Biophys. 1985 Feb 15;237(1):237-43. PubMed PMID: 2578767.