AG490
Code | Size | Price |
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TAR-T2600-10mg | 10mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2600-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2600-25mg | 25mg | £122.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2600-50mg | 50mg | £134.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2600-100mg | 100mg | £149.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2600-200mg | 200mg | £201.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2600-500mg | 500mg | £309.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.
CAS:
133550-30-8
Formula:
C17H14N2O3
Molecular Weight:
294.31
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Angiogenesis; Chromatin/Epigenetic; Stem Cells; Autophagy
Purity:
0.997
SMILES:
Oc1ccc(C=C(/C#N)C(=O)NCc2ccccc2)cc1O
Target:
EGFR; JAK; STAT; Autophagy
References
1. Gazit A, et al. J Med Chem, 1991, 34(6), 1896-1907.
2. Meydan N, et al. Nature, 1996, 379(6566), 645-648.
3. Nielsen M, et al. Proc Natl Acad Sci U S A, 1997, 94(13), 6764-6769.
4. Kirken RA, et al. J Leukoc Biol, 1999, 65(6), 891-899.
5. Sun X, et al. Blood, 2001, 97(7), 22008-22015.
6. Cheppudira BP, et al. Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. Biomed Rep. 2015 Sep;3(5):703-706.
7. Zhu J, Pan X, Lin B, et al. The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells[J]. Acta cirurgica brasileira. 2019, 34(1).