OXSI-2
| Code | Size | Price |
|---|
| TAR-T28281-10mg | 10mg | £559.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
OXSI-2 is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
CAS:
622387-85-3
Formula:
C18H15N3O3S
Molecular Weight:
353.4
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
Cn1cc(C=C2C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2ccccc12
Target:
Syk
References
1. Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 9;18(6). pii: E1238. doi: 10.3390/ijms18061238. PubMed PMID: 28598382; PubMed Central PMCID: PMC5486061.
2. Yaron JR, Rao MY, Gangaraju S, Zhang L, Kong X, Su F, Tian Y, Glenn HL, Meldrum DR. The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem Biophys Res Commun. 2016 Apr 8;472(3):545-50. doi: 10.1016/j.bbrc.2016.03.021. Epub 2016 Mar 9. PubMed PMID: 26970308.
3. Getz TM, Manne BK, Buitrago L, Mao Y, Kunapuli SP. Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in platelets. Thromb Haemost. 2013 Jun;109(6):1131-40. doi: 10.1160/TH12-09-0645. Epub 2013 Mar 28. PubMed PMID: 23571309.
4. Qu L, Li Y, Pan X, Zhang P, LaMotte RH, Ma C. Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons. J Neurosci. 2012 Jul 11;32(28):9554-62. doi: 10.1523/JNEUROSCI.6355-11.2012. PubMed PMID: 22787041; PubMed Central PMCID: PMC3437229.