Daphnetin
Code | Size | Price |
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TAR-T2851-10mg | 10mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2851-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2851-25mg | 25mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2851-50mg | 50mg | £209.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2851-100mg | 100mg | £311.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.
CAS:
486-35-1
Formula:
C9H6O4
Molecular Weight:
178.143
Pathway:
Cytoskeletal Signaling; Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors; Autophagy; Chromatin/Epigenetic
Purity:
0.9982
SMILES:
Oc1ccc2ccc(=O)oc2c1O
Target:
EGFR; PKA; PKC; Parasite; Autophagy
References
1. Yang EB, et al. Biochem Biophys Res Commun, 1999, 260(3), 682-685.
2. Jim?nez-Orozco FA, et al. Eur J Pharmacol. 2011 Oct 1;668(1-2):35-41.
3. Liao MJ, et al. Fundam Clin Pharmacol, 2012.
4. Kane K, et al. Biochem Cell Biol, 2012, 90(5), 657-666.
5. Yang YZ, et al. Am J Trop Med Hyg, 1992, 46(1), 15-20.
6. Lv H, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic Biol Med. 2017 May;106:38-52.