M-31850

TargetMol
Product Code: TAR-T8921
Supplier: TargetMol
CodeSizePrice
TAR-T8921-10mg10mg£103.00
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Quantity:
TAR-T8921-1mL1 mL * 10 mM (in DMSO)£107.00
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Quantity:
TAR-T8921-25mg25mg£130.00
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Quantity:
TAR-T8921-50mg50mg£149.00
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Quantity:
TAR-T8921-100mg100mg£201.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.
CAS:
281224-40-6
Formula:
C28H21N3O4
Molecular Weight:
463.493
Purity:
0.9998
SMILES:
O=C1N(CCNCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c2cccc3cccc1c23

References

Qi Chen, et al. Exploring unsymmetrical dyads as efficient inhibitors against the insect ?-N-acetyl-D-hexosaminidase OfHex2. Biochimie. 2014 Feb;97:152-62. Michael B Tropak, et al. High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol. 2007 Feb;14(2):153-64.