W-7 hydrochloride
| Code | Size | Price |
|---|
| TAR-T20792-1mL | 1 mL * 10 mM (in DMSO) | £95.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20792-10mg | 10mg | £97.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20792-25mg | 25mg | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity
CAS:
61714-27-0
Formula:
C16H22Cl2N2O2S
Molecular Weight:
377.32
Pathway:
Apoptosis; Metabolism; Cytoskeletal Signaling; Neuroscience
Purity:
0.9975
SMILES:
Cl.NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Target:
CaMK; Apoptosis; Myosin; PDE
References
1. Celotto AC, Capellini VK, Restini CB, Baldo CF, Bendhack LM, Evora PR. Extracellular alkalinization induces endothelium-derived nitric oxide dependent relaxation in rat thoracic aorta. Nitric Oxide. 2010 Dec 15;23(4):269-74. doi: 10.1016/j.niox.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20682356.
2. Sekizawa S, Bonham AC. Group I metabotropic glutamate receptors on second-order baroreceptor neurons are tonically activated and induce a Na+-Ca2+ exchange current. J Neurophysiol. 2006 Feb;95(2):882-92. Epub 2005 Sep 28. PubMed PMID: 16192328.
3. Holohean AM, Hackman JC. Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. Br J Pharmacol. 2004 Oct;143(3):351-60. Epub 2004 Aug 31. PubMed PMID: 15339859; PubMed Central PMCID: PMC1575347.
4. Gonda K, Komatsu M, Numata O. Calmodulin and Ca2+/calmodulin-binding proteins are involved in Tetrahymena thermophila phagocytosis. Cell Struct Funct. 2000 Aug;25(4):243-51. PubMed PMID: 11129794.