Metergoline
| Code | Size | Price |
|---|
| TAR-T4008-1mL | 1 mL * 10 mM (in DMSO) | £95.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4008-10mg | 10mg | £99.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
CAS:
17692-51-2
Formula:
C25H29N3O2
Molecular Weight:
403.52
Pathway:
Neuroscience; GPCR/G Protein; Membrane transporter/Ion channel
Purity:
0.9983
SMILES:
CN1C[C@@H](C[C@H]2[C@H]1Cc1cn(c3cccc2c13)C)CNC(=O)OCc1ccccc1
Target:
Dopamine Receptor; 5-HT Receptor; Sodium Channel
References
Knight, A.R.,Misra, A.,Quirk, K., et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn Schmiedebergs Arch. Pharmacol. 370(2), 114-123 (2004)
Yeom, H.D. and Lee, J.-H.?Regulation of human Kv1.4 channel activity by the antidepressant metergoline.?Biol. Pharm. Bull.?39(6),?1069-1072?(2016).
Millan, M.J.,Newman-Tancredi, A.,Lochon, S., et al. Specific labelling of serotonin 5-HT1B receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. Pharmacol. Biochem. Behav. 71(4), 589-598 (2002).
Lee, J.-H.,Liu, J.,Shin, M., et al. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na+ channels expressed in Xenopus oocytes. Acta. Pharmacol. Sin. 35(7), 862-868 (2014).
Knight, J.A.,Smith, C.,Toohey, N., et al. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Mol. Pharmacol. 75(2), 374-380 (2009).