Paraxanthine
| Code | Size | Price |
|---|
| TAR-T4973-25mg | 25mg | £116.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4973-50mg | 50mg | £139.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4973-100mg | 100mg | £168.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4973-200mg | 200mg | £214.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Paraxanthine is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector.
CAS:
611-59-6
Formula:
C7H8N4O2
Molecular Weight:
180.167
Pathway:
Metabolism
Purity:
0.9999
SMILES:
Cn1cnc2[nH]c(=O)n(C)c(=O)c12
Target:
Endogenous Metabolite
References
Guerreiro S , Toulorge D , Hirsch E , et al. Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels[J]. Molecular Pharmacology, 2008, 74(4):980-1989.
Marques L J , Zheng L , Poulakis N , et al. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages.[J]. Am J Respir Crit Care Med, 1999, 159(2):508-511.
Geraets L , Haegens A , Weseler A R , et al. Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine[J]. European Journal of Pharmacology, 2010, 629(1-3):132-139.
Jiang M , Kameda K , Han L K , et al. Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum[J]. Planta Medica, 1998, 64(04):375-377.