Cisplatin

TargetMol
Product Code: TAR-T1564
Supplier: TargetMol
CodeSizePrice
TAR-T1564-50mg50mg£93.00
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Quantity:
TAR-T1564-100mg100mg£104.00
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Quantity:
TAR-T1564-500mg500mg£148.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
CAS:
15663-27-1
Formula:
Cl2H6N2Pt
Molecular Weight:
300.05
Pathway:
DNA Damage/DNA Repair; Autophagy; Apoptosis; Cell Cycle/Checkpoint
Purity:
0.9962
SMILES:
N.N.Cl[Pt]Cl
Target:
DNA Alkylator/Crosslinker; Ferroptosis; DNA/RNA Synthesis; Autophagy

References

1. Cummings BS, et al. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 2002 Jul;302(1):8-17. 10. Liu L, Liu S, Deng P, et al. Targeting the IRAK1-S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma[J]. Cancer Research. 2. Lieberthal W, et al. Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis. Am J Physiol. 1996 Apr;270(4 Pt 2):F700-8. 3. Park HR, et al. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer. 2009 Mar 17;9:85. 4. Molthoff CF, et al. Comparison of 131I-labelled anti-episialin 139H2 with cisplatin, cyclophosphamide or external-beam radiation for anti-tumor efficacy in human ovarian cancer xenografts. Int J Cancer. 1992 Apr 22;51(1):108-15. 5. Xu C, Zhao W, Huang X, et al. TORC2/3-mediated DUSP1 upregulation is essential for human decidualization[J]. Reproduction. 2021, 1(aop). 6. Shao C S, Zhou X H, Zheng X X, et al. Ganoderic acid D induces synergistic autophagic cell death except for apoptosis in ESCC cells[J]. Journal of Ethnopharmacology. 2020, 262: 113213. 7. Wu Y, Zhou L, Wang Z, et al. Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library[J]. Cancer Biology & Medicine. 2020, 17(3): 782. 8. Wang C, Xiong M, Yang C, et al. PEGylated and Acylated Elabela Analogues Show Enhanced Receptor Binding, Prolonged Stability, and Remedy of Acute Kidney Injury[J]. Journal of Medicinal Chemistry. 2020 9. Kang C L, Qi B, Cai Q Q, et al. LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription. Theranostics. 2019, 9(15): 4421.