Phloretin
Code | Size | Price |
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TAR-T2924-250mg | 250mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2924-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2924-500mg | 500mg | £116.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.
CAS:
60-82-2
Formula:
C15H14O5
Molecular Weight:
274.272
Pathway:
GPCR/G Protein; Metabolism
Purity:
0.9974
SMILES:
Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
Target:
SGLT; transporter; Endogenous Metabolite
References
1. Chan SS, et al. Am J Physiol, 1962, 203, 975-979.
2. Idris I, et al. Diabetes Obes Metab, 2009, 11(2), 79-88.
3. Crespy V, et al. J Nutr, 2001, 131(12), 3227-3230.
4. Fenton RA, et al. Proc Natl Acad Sci U S A, 2004, 101(19), 7469-7474.