Hydroorotic acid
| Code | Size | Price |
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| TAR-T32116-50mg | 50mg | £304.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hydroorotic acid, a derivative of orotic acid, can be used as an intermediate in pyrimidine biosynthesis.
CAS:
155-54-4
Formula:
C5H6N2O4
Molecular Weight:
158.113
Purity:
0.98
SMILES:
OC(=O)C1CC(=O)NC(=O)N1
References
1. Tiwari K, Kumar R, Dubey VK. Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition. Biochimie. 2016 Dec;131:45-53. doi: 10.1016/j.biochi.2016.09.009. Epub 2016 Sep 17. PubMed PMID: 27650727.
2. Duley JA, Henman MG, Carpenter KH, Bamshad MJ, Marshall GA, Ooi CY, Wilcken B, Pinner JR. Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine. Mol Genet Metab. 2016 Sep;119(1-2):83-90. doi: 10.1016/j.ymgme.2016.06.008. Epub 2016 Jun 14. PubMed PMID: 27370710.
3. Alves CN, Silva JR, Roitberg AE. Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study. Phys Chem Chem Phys. 2015 Jul 21;17(27):17790-6. doi: 10.1039/c5cp02016f. Epub 2015 Jun 19. PubMed PMID: 26087682.
4. Peng WF, Huang CY. Allantoinase and dihydroorotase binding and inhibition by flavonols and the substrates of cyclic amidohydrolases. Biochimie. 2014 Jun;101:113-22. doi: 10.1016/j.biochi.2014.01.001. Epub 2014 Jan 10. PubMed PMID: 24418229.