L-Kynurenine
| Code | Size | Price |
|---|
| TAR-T4928-50mg | 50mg | £104.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4928-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.
CAS:
2922-83-0
Formula:
C10H12N2O3
Molecular Weight:
208.217
Pathway:
Immunology/Inflammation; Metabolism
Purity:
0.9991
SMILES:
N[C@@H](CC(=O)c1ccccc1N)C(O)=O
Target:
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite
References
Widner B , Sepp N , Kowald E , et al. Degradation of tryptophan in patients with systemic lupus erythematosus[J]. Oxygen Transport to Tissue XXXIII, 1999, 467:571-577.
Moyer BJ, et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGF?, and IDO1. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24.
Sakakibara K, et al. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. J Pharmacol Sci. 2015 Sep;129(1):31-7.
Kolho K L , Pessia A , Jaakkola T , et al. Faecal and serum metabolomics in paediatric inflammatory bowel disease[J]. Journal of Crohns & Colitis, 2017, 11(3):321-334.
Fukushima T , Iizuka H , Yokota A , et al. Quantitative Analyses of Schizophrenia-Associated Metabolites in Serum: Serum D-Lactate Levels Are Negatively Correlated with Gamma-Glutamylcysteine in Medicated Schizophrenia Patients[J]. PLOS ONE, 2014, 9.
Enhanced Tryptophan Degradation in Systemic Lupus Erythematosus[J]. Immunobiology, 2000, 201(5):0-630.
Hartai Z , Klivenyi P , Janaky T , et al. Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease[J]. Journal of the Neurological Sciences, 2005, 239(1):31-35.