Rotundine
Code | Size | Price |
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TAR-T6648-50mg | 50mg | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6648-1mL | 1 mL * 10 mM (in DMSO) | £118.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6648-100mg | 100mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6648-500mg | 500mg | £227.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
CAS:
483-14-7
Formula:
C21H25NO4
Molecular Weight:
355.434
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.998
SMILES:
COc1cc2CCN3Cc4c(C[C@H]3c2cc1OC)ccc(OC)c4OC
Target:
Dopamine Receptor; 5-HT Receptor
References
Wu D, Wang P, Zhao C, et al.Levo-tetrahydropalmatine Ameliorates Neuropathic Pain by Inhibiting the Activation of the Clec7a-MAPK/NF-?B-NLRP3 Inflammasome Axis.Phytomedicine.2023: 155075.
Liu YL, et al. Acta Pharmacol Sin, 2005, 26(5), 533-538.
Wang JB, et al. Future Med Chem, 2012, 4(2), 177-186.