Ifosfamide
Code | Size | Price |
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TAR-T1055-100mg | 100mg | £103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1055-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1055-200mg | 200mg | £116.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1055-500mg | 500mg | £147.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic activity. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.
CAS:
3778-73-2
Formula:
C7H15Cl2N2O2P
Molecular Weight:
261.08
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9986
SMILES:
ClCCNP1(=O)OCCCN1CCCl
Target:
DNA Alkylator/Crosslinker; DNA/RNA Synthesis
References
1. Chang TK, et al. Cancer Res, 1997, 57(10), 1946-1954.
2. Dechant KL, et al. Drugs, 1991, 42(3), 428-467.
3. Chen L, et al. Cancer Res, 1996, 56(6), 1331-1340.
4. Heymann D, et al. Bone, 2005, 37(1), 74-86.
5. Ribeiro RA, et al. J Urol, 2002, 167(5), 2229-2234.
6. Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232(1):182-92.
7. Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91(5):357-68.