Hydralazine hydrochloride
| Code | Size | Price |
|---|
| TAR-T1613-100mg | 100mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T1613-200mg | 200mg | £117.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
CAS:
304-20-1
Formula:
C8H9ClN4
Molecular Weight:
196.64
Pathway:
Metabolism; Neuroscience; Chromatin/Epigenetic
Purity:
0.9986
SMILES:
Cl.NNc1nncc2ccccc12
Target:
MAO; HIF/HIF Prolyl-Hydroxylase
References
1. Mazari L, et al. Proc Natl Acad Sci U S A,2007, 104(15), 6317-6322.
2. Burcham PC, et al. Mol Pharmacol,2006, 69(3), 1056-1065.
3. Leiro JM, et al. Int Immunopharmacol,2004, 4(2), 163-177.
4. Hamann K, et al. J Neurochem,2008, 104(3), 708-718.
5. Kaminskas LM, et al. J Pharmacol Exp Ther,2004, 310(3), 12003-12010.