Phosphorylethanolamine
| Code | Size | Price |
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| TAR-T4881-1g | 1g | £94.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. PE is a precursor of phospholipid synthesis and a product of phospholipid breakdown. Phosphomonoesters are present at much higher levels in the brain than in other organs. In developing the brain, phosphomonoesters are normally elevated during the period of neuritic proliferation. This also coincides with the occurrence of normal programmed cell death and synaptic pruning in developing the brain. These findings are consistent with the role of phosphomonoesters in membrane biosynthesis. PE shows a strong structural similarity to the inhibitory neurotransmitter, GABA, and the GABAB receptor partial agonist, 3-amino-propylphosphonic acid. PE is a phosphomonoester which is decreased in post-mortem Alzheimer's disease (AD) brain.
CAS:
1071-23-4
Formula:
C2H8NO4P
Molecular Weight:
141.063
Pathway:
; Metabolism
Purity:
0.9959
SMILES:
NCCOP(O)(O)=O
Target:
Endogenous Metabolite
References
Li G, et al. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum[J]. Development, 2001, 128(18):3473-3483.
Klunk W E, et al. Structural determinants of activity at the GABAB receptor. A comparison of phosphoethanolamine and related GABA analogs.[J]. Mol Chem Neuropathol, 1995, 26(1):15-30.
Klunk W E, et al. Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites[J]. Life Sciences, 1995, 56(26):2377.