Naphthazarin
| Code | Size | Price |
|---|
| TAR-T8678-100mg | 100mg | £121.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects
CAS:
475-38-7
Formula:
C10H6O4
Molecular Weight:
190.154
Pathway:
Apoptosis
Purity:
0.9987
SMILES:
Oc1ccc(O)c2C(=O)C=CC(=O)c12
Target:
Apoptosis
References
Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):369-74.
Yang N, Zheng R R, Chen Z Y, et al. A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption. Biomaterials Science. 2022, 10(6): 1575-1581
Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90(9):1842-9.