Cell Counting Kit-8 (CCK-8)

TargetMol
Product Code: TAR-C0005
Product Group: Cell Based Assays
Supplier: TargetMol
CodeSizePrice
TAR-C0005-1mL1 mL£86.00
Quantity:
TAR-C0005-5mL5 mL£109.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-C0005-10mL10 mL£134.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-C0005-30mL30 mL£218.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-C0005-100mL100 mL£510.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Further Information

Bioactivity:
Cell Counting Kit-8 (CCK-8) allows very convenient assays by utilizing the highly water-soluble tetrazolium salt WST-8 [2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium,monosodium salt] produces a water-soluble formazan dye upon reduction in the presence of an electron carrier. Cell Counting Kit-8 is a one-bottle solution; no premixing of components is required. Cell Counting Kit- 8, being nonradioactive, allows sensitive colorimetric assays for the determination of the number of viable cells in cell proliferation and cytotoxicity assays.
CAS:
C0005

References

Wang L, Li R, Zang Z, et al.6-Methoxydihydrosanguinarine exhibits cytotoxicity and sensitizes TRAIL-induced apoptosis of hepatocellular carcinoma cells through ROS-mediated upregulation of DR5.Medical Oncology.2023, 40(9): 266. Cai J, Gao L, Wang Y, et al. TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway. Translational Oncology. 2022, 19: 101391. Wu J, Tan Z, Li H, et al. Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O?GlcNAcylation of cyclin?dependent?like kinase 5. Journal of Pineal Research. 021, 71(3): e12765. Liang X L, Ouyang L, Yu N N, et al.Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.Journal of Pharmaceutical Analysis.2023 Li P, Hao Z, Liu H, et al. Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets. Biology-Basel. 2021, 10(3): 250. Liu K, Gao X, Hu C, et al. Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress. Redox Biology. 2022: 102460. Zhou Y, Lin B, Li K, et al. Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma. Frontiers in Oncology. 2021: 3636. Gu L, Chen Y, Li X, et al. Integrated Analysis and Identification of Critical RNA-Binding Proteins in Bladder Cancer. Cancers. 2022, 14(15): 3739. Nan G, Huang L, Li Y, et al. Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors. European Journal of Medicinal Chemistry. 2022, 234: 114252 Lv B, Ma J, Wang Y, et al. Mitochondria-Targeted Mesoporous Organic Silica Nanoplatforms for Overcoming Cisplatin Resistance by Disturbing Mitochondrial Redox Homeostasis. Frontiers in Chemistry. 2022, 10 Luo W, Xu H, Xu L, et al. Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation. Glia. 2022;1?21. Wang T, Wang C, Han J, et al.?-catenin facilitates fowl adenovirus serotype 4 replication through enhancing virus-induced autophagy.Veterinary Microbiology.2022: 109617. Tuo Y, Tang Y, Yang R, et al.Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting AdeB.International Journal of Biological Macromolecules.2023: 126109. Li C, Wang W, Sun Y, et al. Selective sorting and?secretion of?hY4 RNA fragments into?extracellular vesicles mediated by?methylated YBX1 to?promote lung cancer progression. Journal of Experimental & Clinical Cancer Research. 2022, 41(1): 1-20 Tang Y, Xiao S, Wang Z, et al. A Prognostic Model for Acute Myeloid Leukemia Based on IL-2/STAT5 Pathway-Related Genes. Frontiers in Oncology. 2022, 12: 785899-785899. Hu G, Cui Z, Chen X, et al.Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism?Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu.Advanced Science.2023: 2206439. Liu Y, Jin R, Lu H, et al. Fragment-Based Discovery of AF9 YEATS Domain Inhibitors. International Journal of Molecular Sciences. 2022, 23(7): 3893. Bu X, Qu X, Guo K, et al. CD147 confers temozolomide resistance of glioma cells via the regulation of ?-TrCP/Nrf2 pathway. International Journal of Biological Sciences. 2021, 17(12): 3013-3023. Zhu Y, Yang J, Li Y, et al.Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.Medical Oncology.2023, 40(5): 130. Yang X, Mei C, Ma X, et al. m6A Methylases Regulate Myoblast Proliferation, Apoptosis and Differentiation. Animals. 2022, 12(6): 773. Zhang H, Liu J, Dang Q, et al.Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway.BMC Molecular and Cell Biology.2022, 23(1): 1-13. Wu L L, Jiang W M, Liu Z Y, et al.AMG-510 and cisplatin combination increases antitumor effect in lung adenocarcinoma with mutation of KRAS G12C: a preclinical and translational research.Discover Oncology.2023, 14(1): 91. Wei J, Chen X, Li Y, et al. Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78?FOXM1?KIF20A pathway. Acta Pharmaceutica Sinica B. 2022 Yu P, Luo J, Song H, et al. N-acetylcysteine Ameliorates Vancomycin-induced Nephrotoxicity by Inhibiting Oxidative Stress and Apoptosis in the in vivo and in vitro Models. International Journal of Medical Sciences. 2022, 19(4): 740-752 Cai Y, Chen S, Jiang X, et al.LncRNA X Inactive Specific Transcript Exerts a Protective Effect on High Glucose-Induced Podocytes by Promoting the Podocyte Autophagy via miR-30d-5p/BECN-1 Axis.International Journal of Endocrinology.2023 Sun Z, Yan T, Jiang H, et al.Claudin-3 facilitates the progression and mediates the tumorigenic effects of TGF-? in glioblastoma multiforme.Medical Oncology.2023, 40(9): 268. Wang K, Ou Z, Deng G, et al. The Translational Landscape Revealed the Sequential Treatment Containing ATRA Plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy. Pharmaceutics. 2022, 14(11): 2329. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977. Wang R, Dong S, Xia R, et al.Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway.European Journal of Pharmacology.2023: 175985. Xie H, Xu W, Liang J, et al.Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma.Bioorganic Chemistry.2023: 106762. Zhang H, Hu H, Dai Y, et al.A conductive multifunctional hydrogel dressing with the synergistic effect of ROS-scavenging and electroactivity for the treatment and sensing of chronic diabetic wounds.Acta Biomaterialia.2023 Qu X, Liu H, Song X, et al. Effective degradation of EGFRL858R+ T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. European Journal of Medicinal Chemistry. 2021, 218: 113328. Zeng Z, Li T, Liu X, et al.DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell.Redox Biology.2023: 102916. Li H, He C, Zhu R, et al.Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4R? signaling.Cell Reports.2023, 42(8). Liu X, Yang J, Yang C, et al. Morphine promotes the?malignant biological behavior of?non-small cell lung cancer cells through?the?MOR/Src/mTOR pathway. Cancer cell International. 2021, 21(1): 1-14 Qin Y, Pei Z, Feng Z, et al. Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation Frontiers in cell and developmental biology, 2021, 9: 751593-751593.. Frontiers in cell and developmental biology. 2021, 9: 751593-751593. Cao R, Cao C, Hu X, et al.Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS.Phytomedicine.2023: 155125. Su H Y, Tsai Y C, Tsai H P, et al. Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-?B Pathway. Journal of Molecular Sciences. 2022, 23(9): 4910 Pan J, Su J C, Liu Y H, et al. Stelleranoids A?M, guaiane-type sesquiterpenoids based on [5, 7] bicyclic system from Stellera chamaejasme and their cytotoxic activity. Bioorganic Chemistry. 2021: 105251. Tian L L, Ren H, Xi J M, et al. Diverse anti-inflammation and anti-cancer polyketides isolated from the endophytic fungi Alternaria sp. MG1. Fitoterapia. 2021: 105000. Zhou T, Wu Y, Qian D, et al.OTUD1 Chemosensitizes Triple-negative Breast Cancer to Doxorubicin by Modulating P16 Expression.Pathology-Research and Practice.2023: 154571. Lin M H C, Lai P S, Chang L C, et al. Characterization and Optimization of Chitosan-Coated Polybutylcyanoacrylate Nanoparticles for the Transfection-Guided Neural Differentiation of Mouse Induced Pluripotent Stem Cells. International Journal of Molecular Sciences. 2021, 22(16): 8741. Ma M, Fan A, Liu Z, et al. Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss. Frontiers in Pharmacology. 2022, 13 Han S, Zhang H, Liu X, et al.Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.Ecotoxicology and Environmental Safety.2023, 259: 115063. Zhao J, Zeng Z, Chen Y, et al. Lipid droplets are beneficial for rabies virus replication by facilitating viral budding. Journal of Virology. 2021: JVI. 01473-21. Xie Z S, Zhou Z Y, Sun L Q, et al. Structure-based virtual screening towards the discovery of novel FOXM1 inhibitors. Future Medicinal Chemistry. 2021 (0). Hu J, He Q, Tian T, et al.Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel.OncoTargets and Therapy.2023: 197-210. Jiao L, Xu T, Du X, et al.The Inhibition Effects of Sodium Nitroprusside on the Survival of Differentiated Neural Stem Cells through the p38 Pathway.Brain Sciences.2023, 13(3): 438. Zhang L, Niu W, Lin Y, et al.Multifunctional antibacterial bioactive nanoglass hydrogel for normal and MRSA infected wound repair.Journal of Nanobiotechnology.2023, 21(1): 1-14. Liu Z, Nan P, Gong Y, et al.Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.Biomedicine & Pharmacotherapy.2023, 164: 114897. Zhang W, Wang X, Tang Y, et al.Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway.Biomedicine & Pharmacotherapy.2023, 162: 114591. Wang X, Feng J, Wu R, et al.Garcinol and its analogues: synthesis, cytotoxic activity and mechanistic investigation.Bioorganic Chemistry.2023: 106389. Chen A, Xu M, Chen J, et al. Plasma-based Endogenous Metabolomics Profiling of High-Risk Human Papillomavirus and Their Emerging Roles in the Progression of Cervical Cancer. BioMed Research International. 2021 Zhao X, Lian X, Xie J, et al.Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment.Redox Biology.2023: 102678. Liu X, Meng J, Liao X, et al.A de novo missense mutation in MPP2 confers an increased risk of Vogt?Koyanagi?Harada disease as shown by trio-based whole-exome sequencing.Cellular & Molecular Immunology.2023: 1-14. Luo Z S, Yu X C, Wang C, et al.Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway.Journal of Physiology and Biochemistry.2023: 1-13. Jian X, Yang D, Wang L, et al.CREB1 Silencing Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking NF-?B Signaling.Journal of Cardiovascular Translational Research.2023: 1-15. Chen L, Lu Y, Zhao M, et al.A non?canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT).The Journal of Gene Medicine.2023;e3612. Su Z, Luo M, Chen Z L, et al.Comparison of the Ways in Which Nitidine Chloride and Bufalin Induce Programmed Cell Death in Hematological Tumor Cells.Applied Biochemistry and Biotechnology.2023: 1-11. Hu H, Jiang H, Zhang K, et al. Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice. Biomedicine & Pharmacotherapy. 2022, 156: 113804 Zhang R, Tan Y, Yong C, et al. Pirfenidone ameliorates early pulmonary fibrosis in LPS-induced acute respiratory distress syndrome by inhibiting endothelial-to-mesenchymal transition via the Hedgehog signaling pathway. International Immunopharmacology. 2022, 109: 108805 Huang R, Chen D, Wang H, et al. SFRP2 is a Novel Diagnostic Biomarker and Suppresses the Proliferation of Pituitary Adenoma. Journal of Oncology. 2022 Huang B, He Z.Protein Kinase D1 Correlates with Less Lymph Node Metastasis Risk, Enhanced 5-FU Sensitivity, and Better Prognosis in Colorectal Cancer.The Tohoku Journal of Experimental Medicine.2023 Li X, Gu L, Chen Y, et al.A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway.BMC medicine.2022, 20(1): 1-20. Su J, Thakur A, Pan G, et al.Morus alba derived Kuwanon: A combined with 5?fluorouracil reduce tumor progression via synergistic activation of GADD153 in gastric cancer.MedComm?Oncology.2023, 2(1): e24. Liu X, Xi H, Han S, et al.Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.Ecotoxicology and Environmental Safety.2023, 252: 114571. Lv Q Z, Ni T J H, Li L P, et al. A New Antifungal Agent (4-phenyl-1, 3-thiazol-2-yl) Hydrazine Induces Oxidative Damage in Candida albicans. Frontiers in Cellular and Infection Microbiology. 2020, 10: 557 Zhang L, Liu X, Huang M, et al. Metformin Inhibits HaCaT Cell Proliferation Under Hyperlipidemia Through Reducing Reactive Oxygen Species via FOXO3 Activation. Clinical, Cosmetic and Investigational Dermatology. 2022, 15: 1403. Zhang F, Hu G, Chen X, et al. Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction. Signal Transduction and Targeted Therapy. 2022, 7(1): 1-18 Li J, Sun Y, Sun X, et al. AEG-1 silencing attenuates M2-polarization of glioma-associated microglia/macrophages and sensitizes glioma cells to temozolomide. Scientific reports. 2021, 11(1): 1-12. Zhao Y, Zhao N, Cai Y, et al.An algal lectin griffithsin inhibits Hantaan virus infection in vitro and in vivo.Frontiers in Cellular and Infection Microbiology.2022, 12: 1813. Zhang B, Hou Q, Zhang X, et al.Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.Free Radical Biology and Medicine.2022 Yu Z, Li H, Jia Y Y, et al. Ratiometric co-delivery of doxorubicin and docetaxel by covalently conjugating with mPEG-poly (?-malic acid) for enhanced synergistic breast tumor therapy. Polymer Chemistry. 2020, 11(46): 7330-7339 Jia Q, Fu J, Gao C, et al. MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix. Analytical and Bioanalytical Chemistry. 2022: 1-13 Li Y, Wang Y, Gao L, et al. Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma. Journal of Nanobiotechnology. 2022, 20(1): 1-13. Huang Z X, Zhou S T, Wang J, et al.Remdesivir inhibits Porcine epidemic diarrhea virus infection in vitro.Heliyon.2023 Hou Z, Yan M, Li H, et al.Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.Toxicology Letters.2023 Li Q, Yuan H, Zhao G, et al.ZNF32 prevents the activation of cancer?associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer.The FASEB Journal.2023, 37(4): e22837. Wang S.Piperine Derivatives as Modulators of Amyloid-Beta (A?) Aggregation.University of Waterloo.2023 Xiao Y, Tian J, Wu W C, et al. Targeting central nervous system extracellular vesicles enhanced triiodothyronine remyelination effect on experimental autoimmune encephalomyelitis. Bioactive Materials. 2021 Zhang Y R, Zheng P S. NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes. Cancer Letters. 2022: 215917. Zhang W, Fan Z, Wang F, et al.Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.Oxidative Medicine and Cellular Longevity.2023, 2023. Wang C, Wang T, Hu R, et al.9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3? and HSP90?.Journal of Virology.2023: e01984-22. Tao T, Luo D, Gao C, et al. Src homology 2 domain-containing protein tyrosine phosphatase promotes inflammation and accelerates osteoarthritis by activating ?-catenin. Frontiers in Cell and Developmental Biology. 2021 Apr 9;9:646386. doi: 10.3389/fcell.2021.646386. eCollection 2021. Qin R, Wang T, He W, et al.Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL.Cell Communication and Signaling.2023, 21(1): 27. Li J, Zhang Z, Feng X, et al. Stanniocalcin-2 promotes cell EMT and glycolysis via activating ITGB2/FAK/SOX6 signaling pathway in nasopharyngeal carcinoma. Cell Biology and Toxicology. 2022 Apr;38(2):259-272. doi: 10.1007/s10565-021-09600-5. Epub 2021 Apr 2. Liu X, Wei W, Liu Z, et al. Serum apolipoprotein AI depletion is causative to silica nanoparticles?induced cardiovascular damage. Proceedings of the National Academy of Sciences. 2021, 118(44) Wu Z, Li J, Sun Z, et al. Vlasouliodes AD, four new C30 dimeric sesquiterpenes exhibiting potential inhibition of MCF-7 cells from Vladimiria souliei. Fitoterapia. 2022: 105234 Gao Y, Zhu J, Zhao C, et al. 60Co? induction improves the protective effect of Acetobacter pasteurianus against ionizing radiation in mice. Applied Microbiology and Biotechnology. 2021: 1-11. Zhang Y, Feng P, Wang H, et al. Licochalcone B induces DNA damage, cell cycle arrest, apoptosis, and enhances TRAIL sensitivity in hepatocellular carcinoma cells. Chemico-Biological Interactions. 2022, 365: 110076. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668. Wang C, Hu R, Duan L, et al. The canonical Wnt/?-catenin signaling pathway facilitates pseudorabies virus proliferation and enhances virus-induced autophagy. Veterinary Microbiology. 2022: 109502 Zhao M, Lu T, Bi G, et al.PLK1 regulating chemoradiotherapy sensitivity of esophageal squamous cell carcinoma through pentose phosphate pathway/ferroptosis.Biomedicine & Pharmacotherapy.2023, 168: 115711. Li C, Wang W, Sun Y, et al. Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression. Journal of Experimental & Clinical Cancer Research. 2022, 41(1): 1-20 Tang Y, Xiao S, Wang Z, et al. A Prognostic Model for Acute Myeloid Leukemia Based on IL-2/STAT5 Pathway-Related Genes. Frontiers in Oncology. 2022, 12: 785899-785899. Li S, Deng G, Su J, et al. A novel all-trans retinoic acid derivative regulates cell cycle and differentiation of myelodysplastic syndrome cells by USO1. European Journal of Pharmacology. 2021, 906: 174199. Zhang J, An L, Zhao R, et al.KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.Molecular Carcinogenesis.2023, 62(3): 303-318. Yao S, Yin J, Liu W, et al. A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma. Bioorganic Chemistry. 2022: 106019 Zhu J M, Chen C, Kong M, et al.Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer.European Journal of Medicinal Chemistry.2023: 115829. Zhou J, Lu Y, Jia Y, et al. Ketogenic Diet Ameliorates Lipid Dysregulation in Type 2 Diabetic Mice by Downregulating Hepatic Pescadillo 1. Molecular Medicine. 2022, 28(1): 1-16. Lei L, Wang Y, Liu R, et al.Transfer of miR?4755?5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B.Molecular Carcinogenesis.2023 Tian Z, Xu C, He W, et al.The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP.Cancer Letters.2023: 216439. Feng P, Qi Y, Li N, et al. Scutebarbatine A induces cytotoxicity in hepatocellular carcinoma via activation of the MAPK and ER stress signaling pathways. Journal of Biochemical and Molecular Toxicology. 2021 May;35(5):e22731. doi: 10.1002/jbt.22731. Epub 2021 Jan 29. Li D, Sun A, Zhang L, et al. Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2. Theranostics. 2022; 12(17): 7431-7449 LV X W, Wu X, Liu Z, et al. CD73 Aggravates Alcohol-Related Liver Fibrosis by Promoting Autophagy Mediated Activation of Hepatic Stellate Cells Through Ampk/Akt/Mtor Signaling Pathway. International Immunopharmacology. 2022 Oct 30;113(Pt A):109229. Ding Z, Dai C, Shan W, et al. TNF-? up-regulates Nanog by activating NF-?B pathway to induce primary rat spinal cord astrocytes dedifferentiation. Life Sciences. 2021: 120126. Huo Z, Min D, Zhang S, et al.Discovery of Novel Tubulin CBSI (R)-9k from Indanone Scaffold for the Treatment of Colorectal Cancer.RSC Medicinal Chemistry.2023 Mo S, Huang Z, Ye Z, et al.Ten undescribed eremophilane and guaiane sesquiterpenes from Penicillium roqueforti.Phytochemistry.2023: 113722. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567. Ren Y, Qin S, Liu X, et al.Hyperoxia can Induce Lung Injury by Upregulating AECII Autophagy and Apoptosis Via the mTOR Pathway.Molecular Biotechnology.2023: 1-12. Wang X, Ji Y, Qi J, et al.Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells.Cell Death & Disease.2023, 14(8): 1-13. Wang G, Xu L, Shi R, et al.Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction.The Ocular Surface.2023 Zhao J, Zhou X, Chen B, et al.p53 promotes peroxisomal fatty acid ?-oxidation to repress purine biosynthesis and mediate tumor suppression.Cell Death & Disease.2023, 14(2): 87. Li L, Lv L, Xu J C, et al.RIG-I Promotes Tumorigenesis and Confers Radioresistance of Esophageal Squamous Cell Carcinoma by Regulating DUSP6.International Journal of Molecular Sciences.2023, 24(6): 5586. Lu Y, Shan P, Lu W, et al.ROS-Responsive and Self-Amplifying polymeric prodrug for accelerating infected wound healing.Chemical Engineering Journal.2023: 142311. Wang L, Zhang T, Zheng Y, et al.Combination of irinotecan silicasome nanoparticles with radiation therapy sensitizes immunotherapy by modulating the activation of the cGAS/STING pathway for colorectal cancer.Materials Today Bio.2023: 100809. Gao Y, Xiao X, Luo J, et al. E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. International Journal of Molecular Sciences. 2022, 23(21): 13648. Xiong X, Dang W, Luo R, et al. A graphene-based fluorescent nanoprobe for simultaneous imaging of dual miRNAs in living cells. Talanta. 2020: 121947. Chen L, Qian J, You Q, et al. LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway. Bioengineered. 2021 (just-accepted). Xi H, Hu Z, Han S, et al. FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway. Theriogenology. 2022 Qin, Jiace, et al. DNA polymerase ? deficiency promotes the occurrence of esophageal precancerous lesions in mice. Neoplasia. 23.7 (2021): 663-675. Liang J, Yu D, Luo C, et al.Epigenetic suppression of PGC1? (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas.Nature Communications.2023, 14(1): 3251. Luo J F, Yue L, Wu T T, et al.Triterpenoid and Coumarin Isolated from Astilbe grandis with Anti-Inflammatory Effects through Inhibiting the NF-?B Pathway in LPS-Induced RAW264. 7 Cells.Molecules.2023, 28(15): 5731. Yuan P, Luo Y, Ma L. NIR-triggered hydrogel with dynamic stiffness via ion chelation to modulate macrophage phenotypes. Journal of Polymer Science. 2022;1?10. Huang T H, Chen C J, Lin H C A, et al.Self-Nanoemulsifying Drug Delivery System-Containing the Poorly Absorbed Drug?Valsartan in Post-Bariatric Surgery.International Journal of Nanomedicine.2023: 2647-2658. Zhao T, Li X, Chen Y, et al. Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP/P-gp. Frontiers in pharmacology. 2022, 13. Bai W, Zhu T, Zuo J, et al.Delivery of SAV-siRNA via Exosomes from Adipose-Derived Stem Cells for the Treatment of Myocardial Infarction.Tissue Engineering and Regenerative Medicine.2023: 1-15. Dang L, Li P, Dan W, et al.Glycoproteomic analysis of regulatory effects of bisecting N-glycans on N-glycan biosynthesis and protein expressions in human HK-2 cells.Carbohydrate Research.2023: 108894. Ma J, Wang K, Chai J, et al. High RSK4 Expression Constitutes a Predictor of Poor Prognosis for Patients with Clear Cell Renal Carcinoma. Pathology-Research and Practice. 2021: 153642. Zhang N, Xiong L L, Sun D J, et al. Anti-infammatory scalemic chromanoids and chromenoids from Rhododendron dauricum. Fitoterapia. 2022: 105300. Jin C, Ou Q, Chen J, et al. Chaperone-Mediated Autophagy Plays an Important Role in Regulating Retinal Progenitor Cell Homeostasis. Stem Cell Research & Therapy. 2021 Deng Y, Zhang Y, Chen X H, et al.Antibacterial activity evaluation of pleuromutilin derivatives with 4 (3H)-quinazolinone scaffold against methicillin-resistant Staphylococcus aureus.European Journal of Medicinal Chemistry.2022: 114960. He J, He J.Baicalin mitigated IL?1??Induced osteoarthritis chondrocytes damage through activating mitophagy.Chemical Biology & Drug Design.2023 Zhang S, Lu Y, He X, et al.Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non?small cell lung cancer.Phytotherapy Research.2022 Wan S, Chen X, Yin F, et al.Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer.European Journal of Medicinal Chemistry.2023: 115843. Yin J, Feng Z, Li Z, et al.Synthesis and evaluation of N-sulfonylpiperidine-3-carboxamide derivatives as capsid assembly modulators inhibiting HBV in vitro and in HBV-transgenic mice.European Journal of Medicinal Chemistry.2023: 115141. Zha W, Wang J, Guo Z, et al.Efficient Delivery of VEGF-A mRNA for Promoting Diabetic Wound Healing via Ionizable Lipid Nanoparticles.International Journal of Pharmaceutics.2022: 122565. Yan J, Wu J, Wang Y, et al.A novel RBBP8 (p. E281*) germline mutation is a predisposing mutation in familial hereditary cancer syndrome.Journal of Molecular Medicine.2023: 1-11. Zhu Q, Jiao H, Zhao K, et al.Biomimetic Synthesis and Mechanism of Hydroxyapatite Crystals by Biotemplate of Small Intestinal Submucosa and Bacterial Cellulose.Crystal Research and Technology.2023: 2300037. Xiong Q, Zhou Y, Zhang S, et al.NSD3, a member of nuclear receptor?binding SET domain family, is a potential prognostic biomarker for pancreatic cancer.Cancer Medicine.2023 He Y, Gong F, Jin T, et al.Dose-Dependent Effects in Plasma Oncotherapy: Critical In Vivo Immune Responses Missed by In Vitro Studies.Biomolecules.2023, 13(4): 707. Fan J, Qin Y, Xiao C, et al. Biomimetic PLGA-based nanocomplexes for improved tumor penetration to enhance chemo-photodynamic therapy against metastasis of TNBC. Materials Today Advances. 2022, 16: 100289 Zheng M, Zhang Y, Xu Y, et al.Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1.Journal of Proteome Research.2023 Zhao Y, Huang S, Xie R, et al.Extracellular ATP accelerates cell death and decreases tight junction protein ZO-1 in hypoxic cochlear strial marginal cells in neonatal rats.Cellular Signalling.2023: 110732. Wu L, Lin Y, Gao S, et al.Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling.Frontiers in Pharmacology.2023, 14: 1200843. Zhou L, Zhou J, Chen T, et al. Identification of Ascomycin against Zika virus infection through screening of natural product library. Antiviral Research. 2021: 105210. Wang Y, Zhu M, Liang J, et al. Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H2O2-induced BV-2 microglial cells injury. Bioorganic Chemistry. 2022, 128: 106067 Li W, Gou X, Xu D, et al. Therapeutic effects of JLX001 on neuronal necroptosis after cerebral ischemia?reperfusion in rats. Experimental Brain Research. 2022: 1-16. Zhao C, Le X, Li M, et al.Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model.Respiratory Research.2023, 24(1): 1-18. Cui Y, Lv B, Li Z, et al.Bone?Targeted Biomimetic Nanogels Re?Establish Osteoblast/Osteoclast Balance to Treat Postmenopausal Osteoporosis.Small.2023: 2303494. Yang H, Wu Q, Li J, et al.In Vivo Fate of CXCR2-Overexpressing Mesenchymal Stromal/Stem Cells in Pulmonary Diseases Monitored by Near-Infrared Region 2 Imaging.ACS Applied Materials & Interfaces.2023 Fu D, Huang Y, Wang S, et al. HAGLROS knockdown restrained cell proliferation, migration and invasion and facilitated apoptosis in laryngeal cancer via miR?138?5p/CLN5 axis. Journal of Clinical Laboratory Analysis. 2022: e24712. Dong L, Zhao Y, Sun C, et al.ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18.International Immunopharmacology.2023, 124: 110878. Shi M Y, Wang Y, Shi Y, et al.SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer.Genes & Diseases.2023 Zhai Z, Ouyang W, Yao Y, et al. Dexamethasone-loaded ROS-responsive poly (thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury. Bioactive Materials. 2022 Gao J, Wang N, Zong F, et al.TIPE2 regulates the response of BV2 cells to lipopolysaccharide by the crosstalk between PI3K/AKT signaling and microglia M1/M2 polarization.International Immunopharmacology.2023, 120: 110389. Wang Y Y, Xia K, Wang Z X, et al. Osteocyte exosomes accelerate benign prostatic hyperplasia development. Molecular and Cellular Endocrinology. 2021: 111301. Li M, Zhang R, Ge Q, et al.Chemerin as an Inducer of ? Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes ? Cell Mass Expansion.International Journal of Molecular Sciences.2023, 24(11): 9136. Yang X, Wei W, Tan S, et al. Identification and verification of HCAR3 and INSL5 as new potential therapeutic targets of colorectal cancer. World journal of surgical oncology. 2021, 19(1): 1-12. Xu X, Hou D, Wang Y, et al.Knockdown of NF-?B activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.Molecular Biology Reports.2023: 1-13. Wang J, Zhang Y, Dong S, et al.Bivalent mRNA vaccines against three SARS-CoV-2 variants mediated by new ionizable lipid nanoparticles.International Journal of Pharmaceutics.2023: 123155. Xiong Q, Zhang Z, Yang Y, et al.Kr?ppel-like Factor 6 Suppresses the Progression of Pancreatic Cancer by Upregulating Activating Transcription Factor 3.Journal of Clinical Medicine.2023, 12(1): 200. Che J, Lv H, Yang J, et al. Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2?/ATF4/CHOP pathway in vitro. Cellular Signalling. 2021 Aug;84:110024. doi: 10.1016/j.cellsig.2021.110024. Epub 2021 Apr 24. Tian Q, Zhou Y, Zhu L, et al. Development and validation of a ferroptosis-related gene signature for overall survival prediction in lung adenocarcinoma. Frontiers in Cell and Developmental Biology. 2021, 9. Zheng C, Zhang B, Li Y, et al.Donafenib and GSK?J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression.Advanced Science.2023: 2206798. Tsai C Y, Ko H J, Chiou S J, et al.GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells.Journal of Cell Communication and Signaling.2023: 1-16. Ma Y, Luo L, Liu X, et al. Pirfenidone mediates cigarette smoke extract induced inflammation and oxidative stress in vitro and in vivo. International Immunopharmacology. 2021, 96: 107593. Cai J, Ye Z, Hu Y, et al.FAIM2 is a potential pan-cancer biomarker for prognosis and immune infiltration.Frontiers in oncology.2022, 12. Jing L, Zhai M E, Qian M R, et al.Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer.Cell Death Discovery.2023, 9(1): 406. Zhang G, Yu H, Su J, et al. Identification of Key Genes Associated with Endothelial Cell Dysfun