2',3'-cGAMP sodium
| Code | Size | Price |
|---|
| TAR-T10065L-1mg | 1mg | £270.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T10065L-5mg | 5mg | £532.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T10065L-10mg | 10mg | £871.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
2',3'-cGAMP sodium, a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate immune response to pathogenic cytoplasmic DNA.
Biological Applications:
2',3'-cGAMP, as the second messenger in the cGAS-STING signaling pathway, plays a crucial role in various pathological and physiological processes, including anti-infection, anti-tumor responses, autoimmune diseases, and inflammatory conditions. Consequently, the STING signaling pathway is a promising target for drug development. Additionally, the natural synthesis yield of 2',3'-cGAMP is low, and the phosphodiester bonds in its structure are susceptible to enzymatic degradation. Therefore, structural modifications of 2',3'-cGAMP to enhance stability contribute significantly to its pharmaceutical value.
CAS:
2734858-36-5
Description:
2',3'-cGAMP sodium, a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate immune response to pathogenic cytoplasmic DNA.
Formula:
C20H22N10Na2O13P2
Mechanism of Action:
2',3'-cGAMP can bind to STING, activating a cascade of downstream signaling events. The cGAS-STING signaling pathway serves as an intracellular surveillance system. When DNA from viruses or cancer cells enters the cytoplasm, cGAS (cyclic GMP-AMP synthase) is activated and catalyzes the synthesis of 2',3'-cGAMP from ATP and GTP. 2',3'-cGAMP acts as a warning signal, activating the STING (Stimulator of Interferon Genes) pathway. This ultimately induces the production of type I interferon (IFN-β) and other cytokines, initiating the immune response.
Molecular Weight:
718.37
Purity:
0.98
Research Area:
Anti-infective Research; Tumours; Inflammation; Immune Diseases
SMILES:
OC1([H])[C@](OP(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)(O[Na])=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O[Na])=O
References
Guo X, et al. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation. Sci Rep. 2017;7(1):6355.
Lai J, et al. Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice. Mol Ther. 2021;29(5):1758-1771.
Su M, et al. Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): Synthesis, transmission, and degradation. Biochem Pharmacol. 2022;198:114934.
Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35.