Sphingosine-1-phosphate
| Code | Size | Price |
|---|
| TAR-T21500-1mg | 1mg | £311.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Sphingosine-1-phosphate is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protein coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from sphingosine (HY-113498) or other membrane phospholipids.
CAS:
26993-30-6
Molecular Weight:
379.47
Pathway:
GPCR/G Protein|Metabolism
Purity:
0.98
SMILES:
[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)(COP(=O)(O)O)N
Target:
LPL Receptor|Endogenous Metabolite|S1P Receptor
References
Uhlenbrock K, et al. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell Signal. 2002 Nov;14(11):941-53.
Sanchez T, et al. Structural and functional characteristics of S1P receptors. J Cell Biochem. 2004 Aug 1;92(5):913-22.
An S, et al. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. Mol Pharmacol. 1999 May;55(5):787-94.