Tyrphostin A25
Code | Size | Price |
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TAR-T21622-1mg | 1mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T21622-5mg | 5mg | £125.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T21622-10mg | 10mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T21622-25mg | 25mg | £196.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T21622-50mg | 50mg | £293.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T21622-100mg | 100mg | £408.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
Tyrphostin A25 is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 uM for GPR35 and an EC50 value of 5.3 uM for GPR35.
CAS:
118409-58-8
Molecular Weight:
202.17
Pathway:
GPCR/G Protein|JAK/STAT signaling|Endocrinology/Hormones|Angiogenesis|Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
N#CC(C#N)=CC1=CC(O)=C(O)C(O)=C1
Target:
EGFR|GPR
References
Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989;32(10):2344-2352.
Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994;127(3):859-866.
Erlinge D, et al. Tyrphostin inhibition of ATP-stimulated DNA synthesis, cell proliferation and fos-protein expression in vascular smooth muscle cells. Br J Pharmacol. 1996;118(4):1028-1034.
Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011;585(12):1957-1962.