Psammaplin A
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| TAR-T36303-1mg | 1mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].
CAS:
110659-91-1
Molecular Weight:
664.38
Purity:
0.98
SMILES:
O\N=C(/Cc1ccc(O)c(Br)c1)C(=O)NCCSSCCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
References
Psammaplin A, a Natural Bromotyrosine Derivative From a Sponge, Possesses the
Matthias G J Baud, et al. Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A Against Its Epigenetic Targets. J Med Chem. 2012 Feb 23;55(4):1731-50.