BACE1-IN-5
Code | Size | Price |
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TAR-T10453-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T10453-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T10453-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amyloid-β (Aβ) with an IC 50 of 0.82 nM. BACE1-IN-5 has a medicinal chemistry to improve hERG inhibition and P-gp efflux [1].
CAS:
2581114-83-0
Formula:
C18H16F5N5O2S
Molecular Weight:
461.41
Pathway:
Neuroscience
Purity:
0.98
SMILES:
O=C(C1=NC=C(OCF)N=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)S[C@H](C(F)(F)F)C3)=C2
Target:
BACE|Beta Amyloid
References
Kusakabe KI, et al. Trifluoromethyl Dihydrothiazine-Based ?-Secretase (BACE1) Inhibitors with Robust Central A? Reduction and Minimal Covalent Binding Burden. ChemMedChem. 2019 Oct 27.