Myriocin

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TargetMol
Product Code: TAR-T16165
Supplier: TargetMol
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TAR-T16165-1mL1 mL * 10 mM (in DMSO)Enquire
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TAR-T16165-100mg100mgEnquire
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TAR-T16165-10mg10mgEnquire
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TAR-T16165-500mg500mgEnquire
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TAR-T16165-50mg50mgEnquire
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TAR-T16165-5mg5mgEnquire
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C

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Documents

Further Information

Bioactivity:
Myriocin is a fungal metabolite isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia. Myriocin also is an effective inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin strongly inhibits replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV. It has an IC50 of 3.5 ug/mL for inhibiting HCV infection.
CAS:
35891-70-4
Formula:
C21H39NO6
Molecular Weight:
401.54
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
[C@]([C@H]([C@@H](C/C=C/CCCCCCC(CCCCCC)=O)O)O)(C(O)=O)(CO)N
Target:
Chk

References

He Q, et al. Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes inductionof c-myc in mouse liver. Mycopathologia. 2004 Apr;157(3):339-47. Ciesek S, et al. The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase. J Infect Dis. 2008 Oct 1;198(7):1091-3. Amemiya F, et al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. J Infect Dis. 2008 Feb 1;197(3):361-70.