EMD 527040 hydrochloride
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Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
EMD 527040 hydrochloride is an effective integrin αVβ6 inhibitor. The IC 50 values of EMD 527040 hydrochloride were 6 nM and 1.6 uM to inhibit αVβ6 binding to fibronectin and αVβ6 expression cells to fibronectin, respectively. EMD 527040 hydrochloride shows antifibrotic activity in animal models of biliary fibrosis and is active in vivo.
CAS:
2758431-92-2
Molecular Weight:
623.96
Purity:
0.98
SMILES:
O=C(CCCCNC1=CC=CC=N1)N[C@@H](COCC2=CC=CC=C2)C(NC(C3=CC(Cl)=CC(Cl)=C3)CC(O)=O)=O.Cl
References
Patsenker et al (2008) Inhibition of integrin ?v?6 on cholangiocytes blocks transforming growth factor-? activation and retards biliary fibrosis progression. Gastroenterology 135 660 PMID: 18538673