MS 154N
| Code | Size | Price |
|---|
| TAR-T41157-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
MS 154N is a negative control for MS 154. The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kdvalues are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.
CAS:
2675490-97-6
Molecular Weight:
915.45
Purity:
0.98
SMILES:
O=C1C=2C=CC=C(OCCCCCCCCNC(=O)CCN3CCN(CC3)CCCOC4=CC=5C(=NC=NC5NC6=CC=C(F)C(Cl)=C6)C=C4OC)C2C(=O)N1C7C(=O)N(C(=O)CC7)C
References
Cheng et al (2020) Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 63 1216 PMID: 31895569