EGFR-IN-60
Code | Size | Price |
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TAR-T63769-5mg | 5mg | £1,167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T63769-50mg | 50mg | £2,307.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T63769-100mg | 100mg | £2,898.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
EGFR-IN-60 is an effective, orally active, safe antitumor agent. EGFR-IN-60 significantly inhibits EGFRWT (IC50: 83 nM), EGFRT790M (IC50: 26 nM), EGFRL858R (IC50: 53 nM) and JAK3 (IC50: 69 nM). IN-60 inhibited H1975 cells carrying the EGFRT790M mutation (IC50: 1.32 uM) and A431 cells overexpressing EGFRWT (IC50: 4.96 uM). EGFR-IN-60 increased the Bax/Bcl-2 ratio, which induced apoptosis induction and cell death.
CAS:
2699877-43-3
Molecular Weight:
535.47
Purity:
0.98
SMILES:
CN(C)c1ccc(C=Nn2cnc3NC4=C(C(c5cccc(Cl)c5Cl)c3c2=N)C(=O)CC(C)(C)C4)cc1