Manassantin B
| Code | Size | Price |
|---|
| TAR-TN4490-1mL | 1 mL * 10 mM (in DMSO) | £263.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN4490-5mg | 5mg | £287.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.
CAS:
88497-88-5
Molecular Weight:
716.81
Pathway:
Apoptosis|Stem Cells|MAPK|Microbiology/Virology|JAK/STAT signaling|NF-κb
Purity:
0.98
SMILES:
C[C@H]1[C@](O[C@@]([C@@H]1C)(C2=CC(OC)=C(O[C@@H]([C@H](O)C=3C=C4C(=CC3)OCO4)C)C=C2)[H])(C5=CC(OC)=C(O[C@@H]([C@H](O)C6=CC(OC)=C(OC)C=C6)C)C=C5)[H]
Target:
TNF|STAT|JNK|ERK|Antifection|BCL|p38 MAPK|NF-κB