Physalin A
| Code | Size | Price |
|---|
| TAR-TN4774-5mg | 5mg | £872.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN4774-1mL | 1 mL * 10 mM (in DMSO) | £1,075.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.
CAS:
23027-91-0
Formula:
C28H30O10
Molecular Weight:
526.538
Pathway:
Chromatin/Epigenetic|MAPK|Angiogenesis|Endocrinology/Hormones|Immunology/Inflammation|NF-κb|Apoptosis|Autophagy|JAK/STAT signaling|Stem Cells
Purity:
0.98
SMILES:
[H][C@@]12C(=O)[C@]3(O)O[C@]11[C@@](C)(OC(=O)[C@@]1(O)CC[C@@]1([H])[C@@]3([H])[C@H](O)C=C3CC=CC(=O)[C@]13C)[C@H]1C[C@]2(C)C(=C)C(=O)O1
Target:
BCL|NF-κB|p38 MAPK|p53|Autophagy|JAK|ERK|Androgen Receptor|ROS|STAT|JNK