Duramycin
| Code | Size | Price |
|---|
| TAR-T11124-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T11124-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion in airway epithelium and has the potential for cystic fibrosis treatment.
CAS:
1391-36-2
Formula:
C89H125N23O25S3
Molecular Weight:
2013.3
Purity:
0.98
SMILES:
CC(C)C1NC(=O)C(Cc2ccccc2)NC(=O)C2NC(=O)C(Cc3ccccc3)NC(=O)C3CCCN3C(=O)CNC(=O)C(Cc3ccccc3)NC(=O)C3CNCCCCC(NC(=O)C4NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(NC(=O)C(CSCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(N)CSC4C)C(=O)NC(CSC2C)C(=O)N3)NC1=O)C(O)C(O)=O)C(O)=O
References
Rix A, et al. Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin. Mol Imaging Biol. 2019 Aug 8.
Oliynyk I, et al. Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non-cystic fibrosis epithelia. APMIS. 2010 Dec;118(12):982-90.
Huo L, et al. Insights into the Biosynthesis of Duramycin. Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02698-16.