PROTAC CDK2/9 Degrader-1
Code | Size | Price |
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TAR-T12552-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
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TAR-T12552-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
CAS:
2408641-24-5
Formula:
C40H41N13O7
Molecular Weight:
815.84
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
O=C(NC1=CC=C(C=C1)CN2CCN(C(=O)CCC(=O)NCCNC3=CC=CC=4C(=O)N(C(=O)C34)C5C(=O)NC(=O)CC5)CC2)C6=NNC=C6NC=7N=CN=C8NC=CC87
Target:
CDK
References
Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952.