Thiocillin I
| Code | Size | Price |
|---|
| TAR-T13149-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T13149-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains(MIC of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 ug/mL, 0.5 ug/mL, 4 ug/mL and 0.5 ug/mL, respectively).
CAS:
59979-01-0
Formula:
C48H49N13O10S6
Molecular Weight:
1160.36
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
[H][C@]1(NC(=O)c2csc(n2)[C@@H](NC(=O)c2csc(n2)\C(NC(=O)[C@@]([H])(NC(=O)c2csc(n2)-c2ccc(nc2-c2csc1n2)-c1nc(cs1)-c1nc(cs1)C(=O)N\C(=C/C)C(=O)NC[C@@H](C)O)[C@@H](C)O)=C\C)C(C)(C)O)[C@@H](C)O
Target:
Antibacterial
References
Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11(1):43-7.
Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975.