SNIPER(ABL)-049
Code | Size | Price |
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TAR-T18693-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T18693-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 100 uM[1].
CAS:
T18693
Molecular Weight:
959.14
Purity:
0.98
SMILES:
CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O)=O)=O)CC3)C=C2)=O)C=C1NC5=NC=CC(C6=CC=CN=C6)=N5
References
Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.