Disermolide
| Code | Size | Price |
|---|
| TAR-T24002-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24002-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Disermolide is a polyketide natural product found to stabilize microtubules. Disermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines.
CAS:
127943-53-7
Molecular Weight:
593.802
Purity:
0.98
SMILES:
C[C@@H](C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C)[C@@H](O)[C@H](C)[C@@H](OC(N)=O)[C@@H](C)\C=C/C=C
References
Terwilliger DW, Trauner D. Selective Synthesis of Divergolide I. J Am Chem Soc. 2018 Feb 28;140(8):2748-2751. doi: 10.1021/jacs.7b13092. Epub 2018 Feb 15. PubMed PMID: 29376358.
Ding L, Franke J, Hertweck C. Divergolide congeners illuminate alternative reaction channels for ansamycin diversification. Org Biomol Chem. 2015 Feb 14;13(6):1618-23. doi: 10.1039/c4ob02244k. PubMed PMID: 25464499.
Li SR, Zhao GS, Sun MW, He HG, Wang HX, Li YY, Lu CH, Shen YM. Identification and characterization of the biosynthetic gene cluster of divergolides from Streptomyces sp. W112. Gene. 2014 Jul 1;544(1):93-9. doi: 10.1016/j.gene.2014.04.052. Epub 2014 Apr 24. PubMed PMID: 24768719.
Xu Z, Baunach M, Ding L, Peng H, Franke J, Hertweck C. Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte. Chembiochem. 2014 Jun 16;15(9):1274-9. doi: 10.1002/cbic.201402071. Epub 2014 May 27. PubMed PMID: 24867126.