Rhizopodin
| Code | Size | Price |
|---|
| TAR-T26075-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T26075-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Rhizopodin is a potent natural macrolide antibiotic that effectively affects the actin cytoskeleton at nanomolar concentrations.
CAS:
150346-23-9
Molecular Weight:
1469.856
Purity:
0.98
SMILES:
CO[C@@H](C[C@@H]1OC(=O)C[C@@H](O)C[C@@H](OC)\C=C\C=C\C[C@H](OC)c2coc(C[C@H](O)C(C)(C)[C@H](C[C@H](OC)[C@@H](C)CCC(=O)[C@H](C)[C@@H](C\C=C\N(C)C=O)OC)OC(=O)C[C@@H](O)C[C@@H](OC)\C=C\C=C\C[C@H](OC)c3coc(C[C@H](O)C1(C)C)n3)n2)[C@@H](C)CCC(=O)[C@H](C)[C@@H](C\C=C\N(C)C=O)OC |t:15,17,66,68|
References
Oku N, Matsumoto A, Matsunaga T, Asano Y, Kasai H, Matoba S, Igarashi Y. Two new ring-contracted congeners of rhizopodin illustrate significance of the ring moiety of macrolide toxins on the actin disassembly-mediated cytotoxicity. Chem Pharm Bull (Tokyo). 2014;62(3):294-300. PubMed PMID: 24583785.
Pulukuri KK, Chakraborty TK. Formal synthesis of actin binding macrolide rhizopodin. Org Lett. 2014 Apr 18;16(8):2284-7. doi: 10.1021/ol5008179. Epub 2014 Apr 10. PubMed PMID: 24742162.
Zhang S, Menche D, Zahler S, Vollmar AM, Liebl J, F?rster F. In vitro anti-cancer effects of the actin-binding natural compound rhizopodin. Pharmazie. 2015 Sep;70(9):610-5. PubMed PMID: 26492647.
Dalby SM, Goodwin-Tindall J, Paterson I. Total synthesis of (-)-rhizopodin. Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6517-21. doi: 10.1002/anie.201301978. Epub 2013 May 6. PubMed PMID: 23650089.