BB-3497
| Code | Size | Price |
|---|
| TAR-T26747-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26747-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
BB-3497, a potent inhibitor of Escherichia coli peptide deformylase, has antibacterial activity both in vitro and in vivo.
CAS:
235784-88-0
Molecular Weight:
329.43
Purity:
0.98
SMILES:
[C@H](C(N[C@H](C(N(C)C)=O)[C@@](C)(C)C)=O)(CN(C=O)O)CCCC
References
Guay DR. Drug forecast - the peptide deformylase inhibitors as antibacterial agents. Ther Clin Risk Manag. 2007 Aug;3(4):513-25. PubMed PMID: 18472972; PubMed Central PMCID: PMC2374925.
Sharma A, Sharma S, Khuller GK, Kanwar AJ. In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. Int J Antimicrob Agents. 2009 Sep;34(3):226-30. doi: 10.1016/j.ijantimicag.2009.04.005. Epub 2009 Jun 7. PubMed PMID: 19505802.
Kumari T, Issar U, Kakkar R. Docking modes of BB-3497 into the PDF active site--a comparison of the pure MM and QM/MM based docking strategies. Curr Comput Aided Drug Des. 2014;10(4):315-26. PubMed PMID: 25994638.
Sharma A, Khuller GK, Kanwar AJ, Sharma S. Therapeutic potential of peptide deformylase inhibitors against experimental tuberculosis. J Infect. 2010 Jun;60(6):498-501. doi: 10.1016/j.jinf.2010.03.009. Epub 2010 Mar 25. PubMed PMID: 20346970.