ICI 198615
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
ICI 198615, a novel, potent and selective peptide leukotriene antagonist, may be useful for the the treatment of allergic diseases.
CAS:
104448-53-5
Molecular Weight:
548.61
Purity:
0.98
SMILES:
O=C(OC1CCCC1)NC=2C=CC=3C=NN(C3C2)CC4=CC=C(C=C4OC)C(=O)NS(=O)(=O)C=5C=CC=CC5
References
Smith EF 3rd, Slivjak MJ. ICI 198615 is an antagonist of leukotriene C4, leukotriene D4 and leukotriene E4 vasopressor responses in the conscious rat. Pharmacology. 1990;41(2):57-66. PubMed PMID: 2175920.
Uchida Y, Hamada M, Kameyama M, Ohse H, Nomura A, Hasegawa S, Hirata F. ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Biochem Biophys Res Commun. 1992 Mar 31;183(3):1197-202. PubMed PMID: 1567397.