JE-2147
| Code | Size | Price |
|---|
| TAR-T32285-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32285-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
JE-2147 belongs to a type of compound known as hybrid peptides. The compound contains at least two different kinds of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
CAS:
186538-00-1
Molecular Weight:
575.72
Purity:
0.98
SMILES:
C(NCC1=C(C)C=CC=C1)(=O)[C@H]2N(C([C@H]([C@H](CC3=CC=CC=C3)NC(=O)C4=C(C)C(O)=CC=C4)O)=O)CSC2(C)C
References
Hidaka K, Kimura T, Abdel-Rahman HM, Nguyen JT, McDaniel KF, Kohlbrenner WE, Molla A, Adachi M, Tamada T, Kuroki R, Katsuki N, Tanaka Y, Matsumoto H, Wang J, Hayashi Y, Kempf DJ, Kiso Y. Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket. J Med Chem. 2009 Dec 10;52(23):7604-17. doi: 10.1021/jm9005115. PubMed PMID: 19954246.
Perryman AL, Lin JH, Andrew McCammon J. Optimization and computational evaluation of a series of potential active site inhibitors of the V82F/I84V drug-resistant mutant of HIV-1 protease: an application of the relaxed complex method of structure-based drug design. Chem Biol Drug Des. 2006 May;67(5):336-45. PubMed PMID: 16784458.
Bandyopadhyay P, Meher BR. Drug resistance of HIV-1 protease against JE-2147: I47V mutation investigated by molecular dynamics simulation. Chem Biol Drug Des. 2006 Feb;67(2):155-61. PubMed PMID: 16492163.
Randolph JT, DeGoey DA. Peptidomimetic inhibitors of HIV protease. Curr Top Med Chem. 2004;4(10):1079-95. Review. PubMed PMID: 15193140.