ketoACE
| Code | Size | Price |
|---|
| TAR-T32384-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32384-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
ketoACE is an amide bond between Phe-Gly of tripeptide replaced with ketomethylene.
CAS:
74075-33-5
Formula:
C24H26N2O5
Molecular Weight:
422.47
Purity:
0.98
SMILES:
C(CCC([C@H](CC1=CC=CC=C1)NC(=O)C2=CC=CC=C2)=O)(=O)N3[C@H](C(O)=O)CCC3
References
Almquist RG, Steeger T, Jackson S, Mitoma C. Absorption, metabolism, and excretion studies of carbon 14- and tritium-labeled derivatives of a ketomethylene containing tripeptide. Life Sci. 1985 Jul 29;37(4):299-305. PubMed PMID: 2989647.
Morentin Gutierrez P, Gyte A, deSchoolmeester J, Ceuppens P, Swales J, Stacey C, Eriksson JW, Sj?strand M, Nilsson C, Leighton B. Continuous inhibition of 11?-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice. Br J Pharmacol. 2015 Oct;172(20):4806-16. doi: 10.1111/bph.13251. Epub 2015 Oct 8. PubMed PMID: 26218540; PubMed Central PMCID: PMC4621984.
Ziff J, Rudolph DA, Stenne B, Koudriakova T, Lord B, Bonaventure P, Lovenberg TW, Carruthers NI, Bhattacharya A, Letavic MA, Shireman BT. Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists. ACS Chem Neurosci. 2016 Apr 20;7(4):498-504. doi: 10.1021/acschemneuro.5b00304. Epub 2016 Jan 19. PubMed PMID: 26754558.
Brooks RR, Miller KE, Jones SM, Burns RH, Huang CT. Selectivity of converting-enzyme inhibitors for angiotensin I versus bradykinin hydrolysis reactions. J Pharm Sci. 1990 May;79(5):384-8. PubMed PMID: 2161922.