Validamine
| Code | Size | Price |
|---|
| TAR-T7731-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7731-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Validamine is a natural pseudo-aminosugar.
CAS:
32780-32-8
Formula:
C7H15NO4
Molecular Weight:
177.2
Purity:
0.98
SMILES:
C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](N)C1
References
Xue YP, Qin JW, Wang YJ, Wang YS, Zheng YG. Enhanced production of acarbose and concurrently reduced formation of impurity c by addition of validamine in fermentation of Actinoplanes utahensis ZJB-08196. Biomed Res Int. 2013;2013:705418. doi: 10.1155/2013/705418. Epub 2013 Jan 22. PubMed PMID: 23484146; PubMed Central PMCID: PMC3581085.
Hugelshofer CL, Mellem KT, Myers AG. Synthesis of quaternary ?-methyl ?-amino acids by asymmetric alkylation of pseudoephenamine alaninamide pivaldimine. Org Lett. 2013 Jun 21;15(12):3134-7. doi: 10.1021/ol401337p. Epub 2013 Jun 7. PubMed PMID: 23746325; PubMed Central PMCID: PMC3884032.
Asamizu S, Yang J, Almabruk KH, Mahmud T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J Am Chem Soc. 2011 Aug 10;133(31):12124-35. doi: 10.1021/ja203574u. Epub 2011 Jul 18. PubMed PMID: 21766819; PubMed Central PMCID: PMC3162038.
Schalli M, Wolfsgruber A, Gonzalez Santana A, Tysoe C, Fischer R, St?tz AE, Thonhofer M, Withers SG. C-5a-substituted validamine type glycosidase inhibitors. Carbohydr Res. 2017 Feb 22;440-441:1-9. doi: 10.1016/j.carres.2017.01.006. Epub 2017 Jan 13. PubMed PMID: 28135569.